SEQUOIA PHARMACEUDICAL
A SEMI NON-PROFIT PHARMACEUDICAL DEVELOPMENT AND SUPPLIMENT COMPANY…
A PAY WHAT YOU CAN AFFORD MEDICAL COMPANY ALL MEDICATIONS FREE FOR PATIENTS WITH INCOME LESS THAN 300,000 A YEAR.
Zigeunertränen Contra-Tumor Supplement
Zigeunertränen Contra-Tumor Supplement
Although our independent research points to Zigeunertranen being a powerful anti-cancer medicine zigeunertranen has not yet been proven to be an FDA (WHO ROBERT REFERS TO AS PFIZER EMPLOYEES) approved pharmaceutical. it is an extremely powerful anti-oxidant, and has been proven to reduce tumor size in cancer patients by the National Institute of Health.
SEQUOIA PHARMCEUDICAL
Introduction
Redwood (Sequoia sempervirens) and cedar (Cedrus spp.) trees are reservoirs of bioactive compounds—polyphenols, terpenoids, and essential oils—with significant pharmaceutical potential. Encapsulating these botanical extracts into microparticles can enhance stability, control release, and target delivery, opening avenues for antimicrobial, antioxidant, anti-inflammatory, and anticancer therapies.
Key Phytochemicals
Cedar essential oils
α-himachalene, β-himachalene, γ-himachalene
Cedrol and thujopsene
Known for antimicrobial, anti-inflammatory, insect-repellent activities
Redwood heartwood and bark
Proanthocyanidins and taxifolin (antioxidant, vascular-protective)
Tannins with astringent and potential antitumor effects
Cellulose and lignin fractions for biocompatible carrier matrices
Extraction and Isolation
Steam distillation for cedar oils, retaining volatile terpenoids
Supercritical CO₂ extraction of redwood polyphenols, maximizing yield and purity
Solvent partitioning (methanol, ethanol) to fractionate polar and nonpolar constituents
Ultrafiltration and chromatography to isolate high-value flavonoids
Microparticle Formulation Techniques
Spray‐drying • Rapid drying of emulsions containing extract and carrier (maltodextrin, gum arabic) • Produces spherical particles, 1–20 µm
Emulsion‐Solvent Evaporation • Oil-in-water or water-in-oil emulsions with biodegradable polymers (PLGA, chitosan) • Yields tunable release profiles
Coaxial Electrospray • Core–shell microparticles encapsulating cedar oil core with polymer shell • Enables precise control of diameter (100 nm–5 µm)
Supercritical Anti-Solvent (SAS) • Uses CO₂ to precipitate compounds into microparticles without heat degradation • Ideal for thermolabile redwood polyphenols
Physicochemical Characterization
Particle size and distribution via laser diffraction and dynamic light scattering
Morphology using scanning electron microscopy (SEM)
Encapsulation efficiency and loading capacity by HPLC quantification
Surface charge (zeta potential) for colloidal stability
In vitro release kinetics in simulated biological fluids
Pharmacological Applications
Antimicrobial wound dressings • Cedar-oil microparticles embedded in hydrogel dressings • Sustained release combats bacterial biofilms
Antioxidant nutraceuticals • Redwood polyphenol microparticles in oral tablets • Protects endothelial cells from oxidative stress
Anti-inflammatory topicals • Chitosan-coated cedar oil microspheres in creams • Reduces cytokine release in keratinocyte cultures
Anticancer delivery systems • Taxifolin-loaded PLGA microspheres for controlled doxorubicin co-delivery • Enhanced cytotoxicity in breast and colon cancer cell lines
In Vitro and In Vivo Studies
In vitro assays demonstrate MIC reductions against MRSA and Candida spp.
Antioxidant capacity (DPPH, ABTS assays) correlates with microparticle release profiles
Rodent wound-healing models show accelerated closure and reduced inflammation
Xenograft tumor models reveal improved survival and reduced off-target toxicity
Safety, Toxicity, and Regulatory Considerations
Cytotoxicity screening in human dermal fibroblasts and hepatocytes
Hemolysis assays ensure red blood cell compatibility
Maximum tolerated dose studies in rodents inform first-in-human estimates
GRAS status for carriers (maltodextrin, gum arabic) accelerates regulatory approval
Challenges and Future Directions
Scaling up extraction and microparticle production while maintaining batch consistency
Integrating redwood and cedar waste streams into circular bioeconomy models
Exploring targeted delivery via surface-modified microparticles (antibodies, peptides)
Clinical trials to validate efficacy in chronic wound management, cardiovascular protection, and cancer therapy
Combining botanical microparticles with synthetic drugs for synergistic formulations
Harnessing the unique chemistries of redwood and cedar through innovative microparticle technologies offers a promising frontier in pharmaceutical development. By addressing formulation challenges and rigorously validating bioactivity, these natural resources can be transformed into next-generation therapeutics for global health.
HYDROGENIUM PRAEDITUS CEDER OLEUM
Zigeunertränen
Hydrogenated Cedar Oil: Evaluating Its Anticancer Potential
Introduction
Hydrogenated cedar oil is produced by adding hydrogen atoms to cedarwood essential oil, saturating its terpenoid compounds. This process enhances thermal stability and shelf life, but its impact on biological activity—especially anticancer effects—remains unclear.
Chemical Profile and Hydrogenation Effects
Hydrogenation of cedar oil primarily targets unsaturated sesquiterpenes such as cedrol, himachalene, and thujopsene.
Saturated derivatives exhibit reduced volatility and altered lipophilicity.
Structural modifications may affect cellular uptake and metabolic stability.
No published studies have fully characterized these hydrogenated sesquiterpene derivatives in biological assays.
Preclinical Evidence for Cedarwood Compounds
Non-hydrogenated cedar oil shows promising bioactivities:
Antimicrobial and antifungal effects against bacterial and yeast strains
Anti-inflammatory properties in dermal and respiratory models
Limited in vitro cytotoxicity against certain cancer cell lines
However, none of these studies involve the hydrogenated form of the oil.
Lack of Direct Anticancer Research
A systematic literature search reveals no peer-reviewed articles directly testing hydrogenated cedar oil for cancer treatment. General reviews of hydrogenated vegetable and seed oils do not support their use as anticancer agents.
Proposed Research Directions
To determine whether hydrogenated cedar oil has anticancer potential, rigorous studies are needed:
Extraction & hydrogenation: Standardize the hydrogenation protocol to produce reproducible oil batches.
Physicochemical analysis: Use GC-MS and NMR to profile saturated sesquiterpene derivatives.
In vitro screening: Assess cytotoxicity on a panel of human cancer cell lines vs. normal cells.
Mechanistic assays: Evaluate apoptosis induction, cell-cycle arrest, and reactive oxygen species generation.
In vivo models: Test lead compounds in xenograft or syngeneic tumor models to measure tumor growth inhibition and toxicity.
Safety and Regulatory Considerations
Before human trials, ensure:
Acute and chronic toxicity profiles in rodents
Dermal and inhalation safety assessments
Regulatory compliance for botanical drug development (e.g., FDA’s Botanical Drug Guidance)
Conclusion
Currently, there is no evidence that hydrogenated cedar oil cures cancer. While cedarwood oil contains bioactive terpenes with general antimicrobial and anti-inflammatory effects, the hydrogenated derivatives have not been evaluated for anticancer activity. Well-designed chemical, cellular, and animal studies are essential to explore any potential therapeutic benefits.
HOW TO MAKE HOMEMADE VERSION OF Zigeunertränen
NEARLY AS EFFECTIVE AS PROFESSIONAL GRADE ELIXER
🌿 Homemade Botanical Infusion Recipe
NOTE: ADD AN INCH OF WATER BEFORE ADDING OIL TO HYDROGENATOR BOTTLE!!!!!!!!!
Name: Redwood–Cedar Hydrogen Elixir Purpose: Experimental wellness oil infusion
🧪 Ingredients
Finest-grade sandpaper (for producing ultra-fine sawdust)
Small pieces of redwood and cedar wood
2–3 tablespoons of extra virgin olive oil
Hydrogen-infusing water bottle (available online)
Refrigerator
🛠️ Instructions
Prepare the Sawdust
Use the finest sandpaper available to gently sand redwood and cedar pieces.
Collect the ultra-fine sawdust in a clean container. Aim for a powder-like texture.
Create the Infusion Base
Add 2–3 tablespoons of the sawdust into a small glass jar.
Pour in enough extra virgin olive oil to fully submerge the sawdust. Stir gently.
Hydrogen Infusion Process
Transfer the oil mixture into a hydrogen-infusing water bottle.
Activate the hydrogen infusion cycle 10 times, allowing full saturation.
After each cycle, gently swirl the bottle to mix.
Storage
Once infused, pour the oil back into a clean glass jar.
Seal tightly and refrigerate. Let it rest for 24–48 hours before use.
⚠️ Notes & Cautions
This recipe is not a substitute for medical treatment.
Do not ingest or apply without consulting a healthcare professional.
Redwood and cedar oils can be potent and may cause skin irritation or allergic reactions.
Hydrogen-infused oils are not well-studied in clinical settings.